Isaac Melamed and Melinda Heffron
IMMUNOe Research Centers , Centennial, CO 80112, USA
Academic Editor: Enrico Maggi
Copyright © 2016 I. Melamed and M. Heffron. T
The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effctive in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed with comorbid ADHD and allergy using cetirizine (= 12), sustained-release methylphenidate (= 12), or cetirizine + methylphenidate (= 14). Endpoints compared baseline to post treatment evaluations for allergic rhinitis and ADHD scores. Serum nerve growth factor levels were measured using ELISA. For allergy endpoints, combination therapy produced results superior to individual therapy. For ADHD, similar scores were achieved for individual therapy; however, combination therapy resulted inimproved scores. Nerve growth factor levels were downregulated following this trend. We conclude that ADHD and allergic rhinitis
may have common mechanism and represent a comorbid condition that links the nervous system to the immune system. Further studies are needed.